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The chapter reviews the structure and functional area of decision support systems (DSS) for managing complex social and economic systems (CES). Particular features of building DSS to regulate the labor market in the context and with regard to peculiarities of the rural population, including pensioners are reported. Analytical models are provided in the form of differential equations describing the laws of changing SES performances under study due to migration of the population. The application of cognitive approach to build an analytical subsystem of DSS is substantiated. The peculiarities of building DSS for environmental and economic management are shown.